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Heartburn / Acid Reflux / Gastro Oesophageal Reflux Disease GORD / Gastro Esophageal Reflux Disease GERD

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Reflux -Definition

Gastro Oesophageal Reflux disease is a condition in which the contents of the stomach (Acid, food, bile) regurgitate back into the gullet (Oesophagus) causing symptoms or damage to the gullet.

Incidence/ Epidemiology
It’s a common condition world over and generally about 35% of population suffer from this. 10 -15% of the population will have it bad enough to seek medical advice and testing.

Pathophysiology/ What has possibly gone wrong
In order to understand this one needs to know about the normal defense mechanisms of body that prevent reflux:

  • Integrity of Lower Oesophageal Sphincter
  • A snug Hiatus
  • Some Intra-Abdominal Length of Oesophagus
  • Angle of His

When one or more of these mechanisms are lost then one can get reflux.

Age group/Could I be born with that
Yes, one can be born with this condition. Any age group can be affected and some new born babies can have it as well. Some young children do require surgery for this as well, for most conservative measures are used. On the other end of the spectrum that may become worse or problematic in older age groups in 80 and 90 years old.

What can cause reflux in adult life
Increased weight, Increased pressure in abdomen in pregnancy or heavy lifting can be some of the reasons for contributing towards the development of this condition in adult life.

Symptoms

Symptoms/Risks associated with Reflux

Heartburn can give the following symptoms:

  • Discomfort
  • Bad taste in moth
  • Pain
  • Bad breath
  • Inability to enjoy all types of food
  • Sore throat
  • Voice changes
  • In ability to lie flat at night
  • Sleepless nights
  • Poor Quality of life
  • Side effects of the medicine taken to help GORD

Risks of GERD

Risks and complications of GORD:

  • Oesophagitis (Inflammation of Oesophagus)
  • Bleeding from Oesophagus
  • Sore throat
  • Voice changes
  • Chest pain
  • Poorly controlled asthma
  • Recurrent chest infections
  • Stricture formation
  • Barrett’s Oesophagus (change in the lining of gullet which can lead to cancer)
  • Cancer of Oesophagus (this deadly cancer has low survival rate)

Assessment

Assessment of Reflux:

  • If one is suffering from reflux for longer than a few weeks or months, then its best to seek medical advice from a doctor.
  • The doctor will try a short course of Proton pump inhibitors and reassess the situation. If the symptoms recur then a referral is done to an upper GI (gastro Intestinal) surgeon.
  • Careful assessment of symptoms is done and document and appropriate investigations are carried out.
  • Gastroscopy; an examination of the gullet, stomach and duodenum with a flexible telescope.
  • Barium swallow; is indicated in some cases where a contrast is swallowed and x-rays are done.
  • Oesophageal physiological studies may be needed for further evaluation to check the motility of the gullet and also the quantitative analysis of the severity and duration of reflux.

    Self-treatment
    For occasional reflux one can use over the counter medication to manage the symptoms of reflux. This should not continue for more than a few months.

    Getting advice from a doctor:
    If the reflux persists for more than a few months and one is requiring to take medication to control it then it best to see a doctor for assessment and further advice

Investigations

  • Clinical assessment by a surgeon with specialist interest in GERD taking into consideration the age and exact nature of symptoms and its severity is the most important first step.
  • Gastroscopy (Flexible telescopic examination) 
  • Oesophageal physiological studies 
  • Radiological studies

Management of Reflux

1. Conservative and lifestyle measures

Half of the sufferers from GERD will benefit from conservative measures with occasional need of support from medical treatment. The following measures help to avoid reflux and improve quality of life:

  • Losing weight
  • Taking up regular exercise to lose and maintain weight and improve stomach motility
  • Avoiding coffee
  • Taking peppermint tea
  • Eating small dry meals
  • To stop smoking
  • Avoiding drinking any liquid with meals
  • Avoiding food aggravating the symptoms
  • Citrus, Tomatoes or red wine may aggravate the symptoms
  •  Eating dinner at least three to four hours before going to bed
  • Taking no liquid drinks before sleeping
  • Some walk or gentle activity before going to bed
  • Elevating the head end of the bed
  • Sleeping with extra pillows

Success
These measures can be very helpful and effective in mild GORD.  If effective then variation in lifestyle is worth the effort so that medication and sny interventional procedure could be avoided.

Failures
Sometimes despite best efforts these measures may not be successful and the quality of life may remain poor. In those cases, appropriate medical treatment and medical advice should be sought. A combination of conservative measures and medical treatment may bring the symptoms under control.

2. Medical treatment

If simple measures are not effective then one can use medication. These are in three categories:

  • Antacids
  • H2 Blockers
  • PPIs

Principles of Medical treatment

Antacids are medicines in liquid or chewable tablet forms which neutralize the acid in the stomach.

H2 Blockers or H2 antagonists work by reducing the amount of acid production in stomach. There are three channels involved with acid production in stomach. It tends to act on one of the three to reduce the acid secretion.

PPIs (Proton Pump Inhibitors, work by blocking the proton pump as the name suggests, thus blocking all the three channels of acid production in stomach. These are much stronger than the antacids or H2 blockers.

Success
Medical control is effective in mild to moderate reflux. It’s important to continue strictly with the conservative measures as well to give the best chance to medication. Ideally one should try to use the mildest forms of medication to control the acid reflux; however, PPI’s can offer excellent control in those not responding to Antacids and H2 blockers. PPI’s have been a great success and most widely used medicines in the world for over 30 years now.

Failures
In moderate to severe cases, its likely that after initial control of symptoms the condition may worsen and may either require further courses and/or higher doses of PPIs or a combination of PPIs and H2 blockers for long term (more than 3 months). This is considered as a failure of medical treatment.

3. Surgical treatment

Surgery for reflux is being carried out for nearly 70 years and has stood the test of time. The oldest, commonest and most used operation today is Nissen’s Fundoplication. This is being done with minimal invasive approach, Laparoscopically for nearly 30 years. This offers the better results than another other form of operation.

Professor Amir Nisar has performed this operation and modified this technique over the last 28 years. His latest technique of Laproscopic MiniScarLess (MSL) Amir’s Modified Nissen’s Fundoplication focuses on five main aspects:

  • To reduce the risk of complications associated with the standard anti reflux operations
  • To improve the longevity of the operation and its outcomes
  • To reduce the post operative pain 
  • To offer enhanced recovery in a shorter time
  • To make this operation cosmetically better with almost no scars 

There are other operations available as well and may to suitable to in some very specific situations.

The list of surgical options available for reflux treatment in order of preference are:

  • Laproscopic MiniScarLess (MSL) Amir’s Modified Nissen’s Fundoplication
  • Laproscopic Amir’s Modified Nissen’s Fundoplication
  • Laproscopic Nissen’s Fundoplication 
  • Laproscopic Amir’s Dubai Repair (ADR)
  • Laproscopic Toupet Fundoplication
  • Laproscopic Watson’s repair
  • Rossetti’s modified repair
  • Lindh’s repair
  • Dor Fundoplication
  • Hill’s Collis gastroplasty
  • Belsey Mark I repair
  • Belsey Mark II repair
  • Belsey Mark IV repair

Principles of Surgical Treatments in details
The reason for the best results and success with surgical treatment is obvious; correction of the abnormalities and restoration of the normal anatomy.

All the surgical options are based on the very well understood anatomical principals of:

a) Curing the hiatus hernia and bringing the stomach back to the abdomen from the chest.

b) Tightening of the lax hiatus (opening in the diaphragm) back to normal size

c) Mobilisation of the oesophagus high up in the chest and bringing 5-7 cm of oesophagus back into the abdomen without any pull on it.

d) Recreating the angle of ‘His’ for ink well effect.

e) Making 180-360 degrees wrap with the fundus on the stomach, plicating the lower end of the oesophagus with fundus; fundoplication.

Success
In experienced hands one can expect success of laparoscopic Nissen’s Fundoplication in 96-98 % of the cases with excellent results. Short, medium- and long-term results are better than any other treatment method or surgical approaches.

The operation of Laparoscopic Nissen’s Fundoplication is probably technically the most challenging operation for the surgeons to master. Appropriate training, excellent operating skills and working in high volumes centers is crucial. If a surgeon is not experienced in this procedure and has not performed a large number of these operations, then the risks of failure is high. Complications like long term difficulty in swallowing and recurrent reflux can occur.

Failures
The failure rates of Anti Reflux Surgery are higher with the other surgical and endoscopic options in comparison with the laparoscopic Nissen’s Fundoplication. Laparoscopic Nissen’s Fundoplication is the best treatment option for cure of GERD.

4. Gold Standard for Treatment of Reflux

We believe that the Gold standard for treatment of GERD is Laparoscopic MiniScarLess (MSL) Nissen’s Fundoplication. This is an improvement on Laproscopic Amir’s modified Nissen’s Fundoplication.

Amir’s modified Nissen’s Fundoplication itself was an improved version of the Standard Nissen’s Fundoplication. It offers better results than any other operation in terms of cure of reflux in long term.

Professor Amir Nisar has performed these operations and modified the technique over the last 28 years. His latest technique of Laproscopic MiniScarLess (MSL) Amir’s Modified Nissen’s Fundoplication focuses on five main aspects:

  • To reduce the risk of complications associated with the standard anti reflux operations
  • To improve the longevity of the operation and its outcomes
  • To reduce the post operative pain 
  • To offer enhanced recovery in a shorter time
  • To make this operation cosmetically better with almost no scars 

5. Endoscopic Treatment Options:

These new and old treatments probably have a higher failure rate. Some are experimental and new and long term results are not available.

 

  • TIF (TransOral Incisionless Fundoplication)
  • STRETTA
  • Endokinch
  • Entryx Injection
  • Endostitch

Principles of Endoscopic Treatments
These are based on the principal as if there is no hiatus hernia. Just reinforcing the LOS (Lower Oesophageal Sphincter) with endoscopy will control the reflux. This is the basic flaw with the endoscopic treatment options.

The endoscopic treatment are limited in their flexibility to achieve the correction of all the four anatomical deficits responsible for reflux. It only focuses on just strengthening the Lower Oesophageal Sphincter (LOS) and that too is not reinforced as robustly as the surgically done wrap in laparoscopic Nissen’s Fundoplication.

The only perceived benefit of endoscopy is that it does not involve small cuts on the abdomen. Operating times are similar in laparoscopic Nissen’s fundoplication and Endoscopic procedure; about 60 minutes. Both are carried out under general anaesthetic. Overall recovery time in various aspects is similar as well. The results of laparoscopic Nissen’s Fundoplication are long lasting than other approaches. 

Success
Most of the endoscopic procedures to date have failed and abandoned, like Endostitch, endoKinch and Entryx injections.

Currently TIF and Stretta are being used; long term results are awaited.

Failures
As above

6. Alternative Treatment List of Possible Treatments

Angelchick’s Prosthesis, Linx procedure (Its experimental and long term results are awaited. Its correlation and lessons learned from Angelchick’s prosthesis make one worry about the complications with this technique which has limited application only)

There is no definite evidence of the efficacy of the following:

  • Yoga
  • Homeopathy
  • Physiotherapy
  • Chiropractor
  • Herbal

RISKS ASSOCIATED WITH VARIOUS TREATMENT OPTIONS

Risks of Medical treatment with PPIs

 

  • Increased Risk of Pneumonia
  • Increases risk of Cl. Difficile infection, which can be life threatening
  • Osteoporosis, weak bones and fractures (hip, wrist and spine) due to poor Calcium absorption
  • Anaemia due to inadequate vitamin B12 absorption
  • Higher risk of developing dementia
  • Increased risk of formation of polyps in stomach
  • PPI users are at an increased risk of developing Chronic Kidney disease
  • Acute Interstitial nephritis (AIN)
  • Bleeding
  • Adverse cardiovascular events in patients taking PPIs and blood thinning agent, clopidogrel
  • Slightly increased risk of spontaneous bacterial peritonitis ;especially in liver disease and cirrhotic patients
  • Traveler’s diarrhoea
  • Small Intestinal Bacterial Overgrowth (SIBU)
  • Magnesium deficiency
  • Kidney failure

Other side effects from PPIs:

  • Headaches
  • Light headedness
  • Coated tongue
  • Taste disturbance
  • Tiredness and lethargy
  • Fatigue
  • Abdominal cramps
  • Increased flatulence (gas)
  • Diarrhoea
  • Constipation
  • Changed mood
  • Depression
  • Suicidal tendency
  • Nausea
  • Vomiting
  • Skin rash

Risks with endoscopic treatment

These are also an invasive procedure under general anaesthetic (GA). Risk factors of GA and endoscopy apply:

  • Perforation
  • Bleeding
  • Infection
  • Aspiration
  • Recurrent reflux is common
  • Dysphagia (difficulty in swallowing)
  • Fibrosis and shortening of Oesophagus
  • Need of further treatment

Risks of surgery

Surgery is an invasive procedure and requires a general anaesthetic. Laparoscopic surgery offers quick recovery. The risks of surgery are:

  • Bleeding
  • Infection
  • Damage to surrounding organs
  • Dysphagia (difficulty in swallowing)
  • Recurrent reflux
  • Reduced volume of stomach and some possible weight loss after surgery
  • Gas Bloat
  • Wrap slippage
  • Wrap migration
  • Need for further treatment

 

Comparison of Anti Reflux Treatments

What is the Gold standard for treatment of reflux?
Gold standard for treatment of GERD is Laparoscopic MiniScarLess (MSL) Nissen’s Fundoplication. This is an improvement on Laproscopic Amir’s modified Nissen’s Fundoplication.

Amir’s modified Nissen’s Fundoplication itself was an improved version of the Standard Nissen’s Fundoplication. It offers better results than any other operation in terms of cure of reflux in long term.

Professor Amir Nisar has performed these operations and modified the technique over the last 28 years. His latest technique of Laproscopic MiniScarLess (MSL) Amir’s Modified Nissen’s Fundoplication focuses on five main aspects:

  • To reduce the risk of complications associated with the standard anti reflux operations
  • To improve the longevity of the operation and its outcomes
  • To reduce the post operative pain 
  • To offer enhanced recovery in a shorter time
  • To make this operation cosmetically better with almost no scars 

There are other operations available as well and may to suitable to in some very specific situations.

Laparoscopic Toupet Fundoplication is 2nd best option and can be used in certain situations.

Watson’s repair has a slightly higher risk of recurrence of reflux and need to restarting the medication, than the above two approaches.

Angelchick’s prosthesis was a gadget used in the last millennium and this was a soft silicone band, gently placed around the lower end of oesophagus. In theory it looked good but it proved to be a major disaster and most of these bands eroded through the oesophagus and were either passed by patients in their stools or required extensive and complex surgery to retrieve. Senior surgeons having exposure to these from 90s remember the horrific tales well and avoid using any permanent prosthetic material around the oesophagus, if possible, at all.

Experienced surgeons may be skeptical with Linx (magnetic metallic beads ring placed laparoscopically around the lower gullet), for these reasons.

Professor Amir Nisar has dealt with a few of these complex cases and shred his experience and technique to deal with such complex issues, in United Kingdom, Europe and Asia on many forums.

Endoscopic Entryx injections, hailed as a “simple endoscopic / nonsurgical” treatment by injecting Entryx in the lower Oesophageal Sphincter (LOS) in early 2000’s led to huge complications and poor outcomes resulting in many complications and poor quality of life. The idea was to “beef up” the lower oesophageal sphincter with injection to regain its valve like action. This led to several problems especially severe scarring and shortening of oesophagus. Professor Amir Nisar successfully dealt with many such patients and performed Laparoscopic Nissen’s fundoplication in 2004 and 2005 in England, United Kingdom, after extensive oesophageal lengthening to gain some intraabdominal length of oesophagus.

Professor Amir's Contribution

Authors contribution to Anti Reflux Treatment at International level.

  • Nearly 3000 operations performed over the last 25 years.
  • Professor Nisar has trained surgeons in United kingdom and mentored them to set up Anti Reflux surgery in their centers, safely
  • Anti-Reflux Surgery Trial that was conducted in United Kingdom to assess the safety of Laparoscopic Anti-Reflux surgery in late 90’s. This is the largest trial of this nature to be conducted anywhere. Only very few surgeons from the United Kingdom with excellent experience, track record and good results were chosen to perform surgery on this trial. Professor Nisar was one of the surgeons selected from the country to operate in this elite group; he made a substantial and excellent contribution to trial.
  • Professor Nisar has run live surgery workshops and courses in Europe and Asia to teach senior surgeons to perform anti-reflux surgery safely in their practice. He also provides advice to the surgeons who are already performing this operation.
  • Professor Amir Nisar has worked in tertiary referral centres dealing with such operations in straight forward and complex cases of reflux for more than 24 years. Here he learned, gained experience and later independently dealt with complex cases referred from the other hospitals.
  • The strength of Professor Nisar’s experience is not just because of his years or experience and number of surgeries; greatest understanding of the subject and technique comes from being a faculty on international scenes. Operating head to head with the best surgeons in the world has allowed him exposure to their techniques and learn and understand the best practices.
  • Professor Michael Bailey and Professor Amir Nisar are the first two surgeons in the world to perform Laparoscopic Nissen’s Fundoplication as day case in Royal Surrey County Hospital, Guildford, England United Kingdom. Patient had their surgery done, recovered and discharged on the day of the surgery. The outcomes of same day surgery were presented internationally in 2002 and now this is a standard practice followed by many globally.

Professor Nisar’s personal innovations in Anti Reflux Surgery:

  1. Amir’s Hammock Suture for liver retraction
  2. Amir’s wing flap
  3. Amir’s saddle support
  4. Amir’s Cruroplasty
  5. Amir’s Diamond fixation of the wrap
  6. Amir’s modified Laparoscopic Nissen’s Fundoplication
  7. Amir’s Dubai Repair (ADR)
  8. Amir’s modified MiniScarLess Laparoscopic Nissen’s Fundoplication

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